› 2hog

X-ray diffraction
1.9Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Chk1 Chain: A
Molecule details ›
Chain: A
Length: 322 amino acids
Theoretical weight: 36.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14757 (Residues: 2-307; Coverage: 64%)
Gene names: CHEK1, CHK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 710 1 x 710
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 44.97Å b: 65.53Å c: 58.4Å
α: 90° β: 94.2° γ: 90°
R-values:
R R work R free
0.204 0.204 0.236
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Synthesis of indazole motifs and their medicinal importance: an overview.
Gaikwad et al. (2015)
2 more

8 mentions without citation

Structure-based design, discovery and development of checkpoint kinase inhibitors as potential anticancer therapies.
Matthews et al. (2013)
7 more