Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Thrombin heavy chain (preferred)
PDBe Complex ID:
PDB-CPX-133056 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain
Molecule details ›
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Thrombin light chain
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P00734 (Residues: 328-363; Coverage: 6%)
Sequence domains: Thrombin light chain
Thrombin heavy chain
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Activation peptide fragment 2
Molecule details ›
Chain: P
Length: 79 amino acids
Theoretical weight: 8.69 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4
Length: 79 amino acids
Theoretical weight: 8.69 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P00734 (Residues: 213-291; Coverage: 13%)
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4
