› 2hrb

X-ray diffraction
1.9Å resolution

Crystal Structure of human Carbonyl Reductase 3, complexed with NADP+

Released:
DOI: 10.2210/pdb2hrb/pdb
PDB entry 2hrb coloured by chain, front view.
PDB entry 2hrb coloured by chain, side view.
PDB entry 2hrb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pilka ES, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH
NADPH + a quinone = NADP(+) + a quinol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131138 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonyl reductase [NADPH] 3 Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 30.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75828 (Residues: 6-277; Coverage: 98%)
Gene names: CBR3, SDR21C2
Sequence domains: short chain dehydrogenase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAP 1 x NAP
1 bound ligand:
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 56.356Å b: 60.14Å c: 88.117Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.212 0.264
Expression system: Escherichia coli

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