› 2hwx

X-ray diffraction
1.9Å resolution

Structure of human SMG6 E1282C PIN domain mutant.

Released:
DOI: 10.2210/pdb2hwx/pdb
PDB entry 2hwx coloured by chain, front view.
PDB entry 2hwx coloured by chain, side view.
PDB entry 2hwx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.
Glavan F, Behm-Ansmant I, Izaurralde E, Conti E
EMBO J 25 5117-25 (2006)
PMID: 17053788

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183185 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Telomerase-binding protein EST1A Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 20.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q86US8 (Residues: 1239-1419; Coverage: 13%)
Gene names: C17orf31, EST1A, KIAA0732, SMG6
Sequence domains: PIN domain
Structure domains: 5'-nuclease

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 69.36Å b: 73.34Å c: 37.309Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 0.239
Expression system: Escherichia coli BL21

Quick links

Citations

36 review citations

P bodies: at the crossroads of post-transcriptional pathways.
Eulalio et al. (2007)
35 more

1 mention without citation

Comprehensive classification of the PIN domain-like superfamily.
Matelska et al. (2017)