› 2hz0

X-ray diffraction
2.1Å resolution

Abl kinase domain in complex with NVP-AEG082

Released:
DOI: 10.2210/pdb2hz0/pdb
PDB entry 2hz0 coloured by chain, front view.
PDB entry 2hz0 coloured by chain, side view.
PDB entry 2hz0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.
Cowan-Jacob SW, Fendrich G, Floersheimer A, Furet P, Liebetanz J, Rummel G, Rheinberger P, Centeleghe M, Fabbro D, Manley PW
Acta Crystallogr D Biol Crystallogr 63 80-93 (2007)
PMID: 17164530

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 270 amino acids
Theoretical weight: 31.33 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00519 (Residues: 228-497; Coverage: 24%)
Gene names: ABL, ABL1, JTK7
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GIN 2 x GIN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM1A
Spacegroup: P212121
Unit cell:
a: 34.02Å b: 123.96Å c: 139.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.256
Expression system: Spodoptera frugiperda

Quick links

Citations

19 review citations

Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer.
Pao et al. (2010)
18 more

10 mentions without citation

Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.
Cowan-Jacob et al. (2007)
9 more