› 2i2y

Solution NMR

Solution structure of the RRM of SRp20 bound to the RNA CAUC

Released:
DOI: 10.2210/pdb2i2y/pdb
PDB entry 2i2y coloured by chain, ensemble of 28 models, front view.
PDB entry 2i2y coloured by chain, ensemble of 28 models, side view.
PDB entry 2i2y coloured by chain, ensemble of 28 models, top view.
Source organisms:
Primary publication:
Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.
Hargous Y, Hautbergue GM, Tintaru AM, Skrisovska L, Golovanov AP, Stevenin J, Lian LY, Wilson SA, Allain FH
EMBO J 25 5126-37 (2006)
PMID: 17036044

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148786 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Immunoglobulin G-binding protein G; Serine/arginine-rich splicing factor 3 Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 16.86 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P19909 (Residues: 303-359; Coverage: 10%)
  • Canonical: P84103 (Residues: 1-86; Coverage: 52%)
Gene names: SFRS3, SRP20, SRSF3, spg
Sequence domains:
Structure domains:
(5'-R(*CP*AP*UP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 4 nucleotides
Theoretical weight: 1.2 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: AMBER 7
Expression system: Escherichia coli

Quick links

Citations

19 review citations

RNA-binding proteins: modular design for efficient function.
Lunde et al. (2007)
18 more

6 mentions without citation

Towards deciphering the principles underlying an mRNA recognition code.
Serganov et al. (2008)
5 more