› 2i2z

X-ray diffraction
2.7Å resolution

Human serum albumin complexed with myristate and aspirin

Released:
DOI: 10.2210/pdb2i2z/pdb
PDB entry 2i2z coloured by chain, front view.
PDB entry 2i2z coloured by chain, side view.
PDB entry 2i2z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin.
Yang F, Bian C, Zhu L, Zhao G, Huang Z, Huang M
J Struct Biol 157 348-55 (2007)
PMID: 17067818

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 585 amino acids
Theoretical weight: 66.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

2 bound ligands:
Ligand MYR 5 x MYR
Ligand SAL 1 x SAL
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: C2
Unit cell:
a: 188.409Å b: 38.936Å c: 96.018Å
α: 90° β: 105.32° γ: 90°
R-values:
R R work R free
0.218 0.218 0.262

Quick links

Citations

16 review citations

Lessons from the crystallographic analysis of small molecule binding to human serum albumin.
Curry S. (2009)
15 more

6 mentions without citation

Serum Albumin: A Multifaced Enzyme.
De Simone et al. (2021)
5 more