› 2i46

X-ray diffraction
2.7Å resolution

Crystal structure of human TPP1

Released:
DOI: 10.2210/pdb2i46/pdb
PDB entry 2i46 coloured by chain, front view.
PDB entry 2i46 coloured by chain, side view.
PDB entry 2i46 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M
Nature 445 506-10 (2007)
PMID: 17237768

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188360 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adrenocortical dysplasia protein homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 161 amino acids
Theoretical weight: 17.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96AP0 (Residues: 4-164; Coverage: 35%)
Gene names: ACD, PIP1, PTOP, TINT1, TPP1
Sequence domains: Shelterin complex subunit, TPP1/ACD
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: I4122
Unit cell:
a: 117.246Å b: 117.246Å c: 171.585Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.251
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

138 review citations

How shelterin protects mammalian telomeres.
Palm et al. (2008)
137 more

35 mentions without citation

Finding the end: recruitment of telomerase to telomeres.
Nandakumar et al. (2013)
34 more