› 2i75

X-ray diffraction
2.45Å resolution

Crystal Structure of Human Protein Tyrosine Phosphatase N4 (PTPN4)

Released:
DOI: 10.2210/pdb2i75/pdb
PDB entry 2i75 coloured by chain, front view.
PDB entry 2i75 coloured by chain, side view.
PDB entry 2i75 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell 136 352-63 (2009)
PMID: 19167335

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151342 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 4 Chain: A
Molecule details ›
Chain: A
Length: 320 amino acids
Theoretical weight: 36.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29074 (Residues: 611-926; Coverage: 34%)
Gene name: PTPN4
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P41212
Unit cell:
a: 66.075Å b: 66.075Å c: 144.508Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.224 0.291
Expression system: Escherichia coli

Quick links

Citations

59 review citations

Inside the human cancer tyrosine phosphatome.
Julien et al. (2011)
58 more

3 mentions without citation

PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.
Xu et al. (2021)
2 more