› 2i7p

X-ray diffraction
2.05Å resolution

Crystal structure of human PANK3 in complex with AcCoA

Released:
DOI: 10.2210/pdb2i7p/pdb
PDB entry 2i7p coloured by chain, front view.
PDB entry 2i7p coloured by chain, side view.
PDB entry 2i7p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW
J Biol Chem 282 27984-93 (2007)
PMID: 17631502

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190695 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate kinase 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 362 amino acids
Theoretical weight: 40.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H999 (Residues: 12-368; Coverage: 97%)
Gene name: PANK3
Sequence domains: Fumble
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ACO 4 x ACO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 56.734Å b: 180.17Å c: 77.728Å
α: 90° β: 95.68° γ: 90°
R-values:
R R work R free
0.23 0.211 0.253
Expression system: Escherichia coli BL21(DE3)

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Citations

11 review citations

Clinical and genetic delineation of neurodegeneration with brain iron accumulation.
Gregory et al. (2009)
10 more

5 mentions without citation

Human anti-V3 HIV-1 monoclonal antibodies encoded by the VH5-51/VL lambda genes define a conserved antigenic structure.
Gorny et al. (2011)
4 more