› 2i9a

X-ray diffraction
1.9Å resolution

Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)

Released:
DOI: 10.2210/pdb2i9a/pdb
PDB entry 2i9a coloured by chain, front view.
PDB entry 2i9a coloured by chain, side view.
PDB entry 2i9a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
Barinka C, Parry G, Callahan J, Shaw DE, Kuo A, Bdeir K, Cines DB, Mazar A, Lubkowski J
J Mol Biol 363 482-95 (2006)
PMID: 16979660

Function and Biology Details

Reaction catalysed: 
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133249 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urokinase-type plasminogen activator long chain A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 145 amino acids
Theoretical weight: 16.4 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P00749 (Residues: 21-163; Coverage: 35%)
Gene name: PLAU
Sequence domains: Kringle domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PO4 4 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P1
Unit cell:
a: 47.603Å b: 64.327Å c: 64.623Å
α: 107.62° β: 92.11° γ: 95.75°
R-values:
R R work R free
0.183 0.182 0.208
Expression system: Drosophila melanogaster

Quick links

Citations

15 review citations

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Rijken et al. (2009)
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3 mentions without citation

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