› 2ic4

X-ray solution scattering

Solution structure of the His402 allotype of the Factor H SCR6-SCR7-SCR8 fragment

Released:
DOI: 10.2210/pdb2ic4/pdb
PDB entry 2ic4 coloured by chain, front view.
PDB entry 2ic4 coloured by chain, side view.
PDB entry 2ic4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Associative and structural properties of the region of complement factor H encompassing the Tyr402His disease-related polymorphism and its interactions with heparin.
Fernando AN, Furtado PB, Clark SJ, Gilbert HE, Day AJ, Sim RB, Perkins SJ
J Mol Biol 368 564-81 (2007)
PMID: 17362990

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H Chain: A
Molecule details ›
Chain: A
Length: 187 amino acids
Theoretical weight: 21.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P08603 (Residues: 321-506; Coverage: 15%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

The spectrum of phenotypes caused by variants in the CFH gene.
Boon et al. (2009)
6 more