› 2icf

X-ray diffraction
4.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133835 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Complement C3 beta chain Chain: A
Molecule details ›
Chain: A
Length: 642 amino acids
Theoretical weight: 71.17 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 23-664; Coverage: 39%)
Gene names: C3, CPAMD1
Sequence domains:
Complement C3b alpha' chain Chain: B
Molecule details ›
Chain: B
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 749-1663; Coverage: 56%)
Gene names: C3, CPAMD1
Sequence domains:
V-set and immunoglobulin domain-containing protein 4 Chain: S
Molecule details ›
Chain: S
Length: 119 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y279 (Residues: 19-137; Coverage: 31%)
Gene names: CRIg, UNQ317/PRO362, VSIG4, Z39IG
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand CA 1 x CA
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2221
Unit cell:
a: 97.614Å b: 255.749Å c: 180.302Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.256 0.252 0.33
Expression system: Escherichia coli

Quick links

Citations

36 review citations

Complement-targeted therapeutics.
Ricklin et al. (2007)
35 more

13 mentions without citation

Manipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy.
Ricklin D. (2012)
12 more