› 2id5

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188495 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 477 amino acids
Theoretical weight: 54.27 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q96FE5 (Residues: 40-516; Coverage: 82%)
Gene names: LERN1, LINGO1, LRRN6A, UNQ201/PRO227
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 13 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21212
Unit cell:
a: 201.517Å b: 149.72Å c: 157.486Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.255
Expression system: Cricetulus griseus

Quick links

Citations

17 review citations

Role of leucine-rich repeat proteins in the development and function of neural circuits.
de Wit et al. (2011)
16 more

11 mentions without citation

Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors.
Matsushima et al. (2007)
10 more