› 2iik

X-ray diffraction
2.55Å resolution

Crystal Structure of human peroxisomal acetyl-CoA acyl transferase 1 (ACAA1)

Released:
DOI: 10.2210/pdb2iik/pdb
PDB entry 2iik coloured by chain, front view.
PDB entry 2iik coloured by chain, side view.
PDB entry 2iik coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Papagrigoriou E, Johansson C, Smee C, Kavanagh K, Pike ACW, Sundstrom M, Weigelt J, Edwards A, Arrowsmith CH, Gileadi O, Gorrec F, Umeano C, von Delft F, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
Myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA
(1a) [acetyl-CoA C-acyltransferase]-S-acyl-L-cyteine + acetyl-CoA = 3-oxoacyl-CoA + [acetyl-CoA C-acyltransferase]-L-cyteine
(1a) acetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine = [acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140554 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-ketoacyl-CoA thiolase, peroxisomal Chains: A, B
Molecule details ›
Chains: A, B
Length: 418 amino acids
Theoretical weight: 43.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09110 (Residues: 30-424; Coverage: 93%)
Gene names: ACAA, ACAA1, PTHIO
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 55.147Å b: 96.845Å c: 142.055Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.223
Expression system: Escherichia coli BL21(DE3)

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