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X-ray diffraction
1Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 62 amino acids
Theoretical weight: 6.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06239 (Residues: 59-119; Coverage: 12%)
Gene name: LCK
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand CA 1 x CA
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P3221
Unit cell:
a: 50.31Å b: 50.31Å c: 46.37Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.132 0.132 0.153
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Zinc as a Gatekeeper of Immune Function.
Wessels et al. (2017)
11 more

12 mentions without citation

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
Kan et al. (2023)
11 more