› 2ija

X-ray diffraction
1.7Å resolution

Human N-acetyltransferase 1 F125S mutant

Released:
DOI: 10.2210/pdb2ija/pdb
PDB entry 2ija coloured by chain, front view.
PDB entry 2ija coloured by chain, side view.
PDB entry 2ija coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tempel W, Wu H, Dombrovski L, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Grant DM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148373 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arylamine N-acetyltransferase 1 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18440 (Residues: 2-290; Coverage: 100%)
Gene names: AAC1, NAT1
Sequence domains: N-acetyltransferase
Structure domains: Arylamine N-acetyltransferase fold

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand ACM 1 x ACM
Ligand UNX 7 x UNX
1 modified residue:
Ligand MSE 5 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2
Unit cell:
a: 90.549Å b: 37.558Å c: 88.478Å
α: 90° β: 102.7° γ: 90°
R-values:
R R work R free
0.166 0.164 0.203
Expression system: Escherichia coli

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