› 2imt

X-ray diffraction
1.49Å resolution

The X-ray Structure of a Bak Homodimer Reveals an Inhibitory Zinc Binding Site

Released:
DOI: 10.2210/pdb2imt/pdb
PDB entry 2imt coloured by chain, front view.
PDB entry 2imt coloured by chain, side view.
PDB entry 2imt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.
Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G, Gehring K
Mol Cell 24 677-688 (2006)
PMID: 17157251

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2 homologous antagonist/killer Chain: A
Molecule details ›
Chain: A
Length: 171 amino acids
Theoretical weight: 19.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16611 (Residues: 16-186; Coverage: 81%)
Gene names: BAK, BAK1, BCL2L7, CDN1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 57.247Å b: 53.646Å c: 58.074Å
α: 90° β: 114.87° γ: 90°
R-values:
R R work R free
0.194 0.192 0.22
Expression system: Escherichia coli

Quick links

Citations

43 review citations

The BCL-2 protein family: opposing activities that mediate cell death.
Youle et al. (2008)
42 more

23 mentions without citation

The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.
Luna-Vargas et al. (2016)
22 more