› 2iqc

X-ray diffraction
2.4Å resolution

Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex

Released:
DOI: 10.2210/pdb2iqc/pdb
PDB entry 2iqc coloured by chain, front view.
PDB entry 2iqc coloured by chain, side view.
PDB entry 2iqc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex.
Kowal P, Gurtan AM, Stuckert P, D'Andrea AD, Ellenberger T
J Biol Chem 282 2047-55 (2007)
PMID: 17082180

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192488 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fanconi anemia group F protein Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 23.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NPI8 (Residues: 156-357; Coverage: 54%)
Gene name: FANCF
Sequence domains: Fanconi anemia group F protein (FANCF)
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

1 bound ligand:
Ligand HG 1 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P3121
Unit cell:
a: 96.386Å b: 96.386Å c: 47.963Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.193 0.255
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

How the fanconi anemia pathway guards the genome.
Moldovan et al. (2009)
8 more

9 mentions without citation

Fanconi anemia pathway as a prospective target for cancer intervention.
Liu et al. (2020)
8 more