› 2ivx

X-ray diffraction
1.8Å resolution

Crystal structure of human cyclin T2 at 1.8 A resolution

Released:
DOI: 10.2210/pdb2ivx/pdb
PDB entry 2ivx coloured by chain, front view.
PDB entry 2ivx coloured by chain, side view.
PDB entry 2ivx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
Baumli S, Lolli G, Lowe ED, Troiani S, Rusconi L, Bullock AN, Debreczeni JE, Knapp S, Johnson LN
EMBO J 27 1907-18 (2008)
PMID: 18566585

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130039 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-T2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60583 (Residues: 7-263; Coverage: 35%)
Gene name: CCNT2
Sequence domains:
Structure domains: Cyclin-like

Ligands and Environments

1 bound ligand:
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 43.032Å b: 58.636Å c: 65.634Å
α: 110.63° β: 102.41° γ: 90.12°
R-values:
R R work R free
0.192 0.191 0.223
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

53 review citations

RNA polymerase II elongation control.
Zhou et al. (2012)
52 more

4 mentions without citation

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
Baumli et al. (2008)
3 more