› 2j3o

X-ray diffraction
2.65Å resolution

L-ficolin complexed to N-acetyl-D-glucosamine

Released:
DOI: 10.2210/pdb2j3o/pdb
PDB entry 2j3o coloured by chain, front view.
PDB entry 2j3o coloured by chain, side view.
PDB entry 2j3o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the innate immune recognition specificities of L- and H-ficolins.
Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C
EMBO J 26 623-33 (2007)
PMID: 17215869

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172309 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ficolin-2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 219 amino acids
Theoretical weight: 24.84 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q15485 (Residues: 95-313; Coverage: 76%)
Gene names: FCN2, FCNL
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CA 6 x CA
Ligand ACT 2 x ACT
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 200.52Å b: 84.51Å c: 144.09Å
α: 90° β: 123.57° γ: 90°
R-values:
R R work R free
0.234 0.228 0.283
Expression system: Trichoplusia ni

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Citations

33 review citations

An integrated view of humoral innate immunity: pentraxins as a paradigm.
Bottazzi et al. (2010)
32 more

2 mentions without citation

Structural insights into the innate immune recognition specificities of L- and H-ficolins.
Garlatti et al. (2007)
1 more