› 2j4z

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chains: A, B
Molecule details ›
Chains: A, B
Length: 306 amino acids
Theoretical weight: 35.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14965 (Residues: 100-403; Coverage: 75%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 626 2 x 626
Ligand ARS 3 x ARS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 71.127Å b: 89.445Å c: 94.037Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.249
Expression system: Spodoptera frugiperda

Quick links

Citations

32 review citations

Cell cycle kinases as therapeutic targets for cancer.
Lapenna et al. (2009)
31 more

11 mentions without citation

Rapid calcium-dependent activation of Aurora-A kinase.
Plotnikova et al. (2010)
10 more