› 2j50

X-ray diffraction
3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chains: A, B
Molecule details ›
Chains: A, B
Length: 280 amino acids
Theoretical weight: 32.37 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14965 (Residues: 126-403; Coverage: 69%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 627 2 x 627
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 75.688Å b: 86.782Å c: 86.829Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.268
Expression system: Spodoptera frugiperda

Quick links

Citations

32 review citations

Cell cycle kinases as therapeutic targets for cancer.
Lapenna et al. (2009)
31 more

13 mentions without citation

Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit.
Muhs et al. (2011)
12 more