› 2j67

X-ray diffraction
2.2Å resolution

The TIR domain of human Toll-Like Receptor 10 (TLR10)

Released:
DOI: 10.2210/pdb2j67/pdb
PDB entry 2j67 coloured by chain, front view.
PDB entry 2j67 coloured by chain, side view.
PDB entry 2j67 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer.
Nyman T, Stenmark P, Flodin S, Johansson I, Hammarström M, Nordlund P
J Biol Chem 283 11861-5 (2008)
PMID: 18332149

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189799 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 178 amino acids
Theoretical weight: 21.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BXR5 (Residues: 622-776; Coverage: 20%)
Gene names: TLR10, UNQ315/PRO358
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 66.2Å b: 43.3Å c: 71.3Å
α: 90° β: 101° γ: 90°
R-values:
R R work R free
0.216 0.214 0.266
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

37 review citations

Molecular basis of NF-κB signaling.
Napetschnig et al. (2013)
36 more

36 mentions without citation

Recognition of lipopolysaccharide pattern by TLR4 complexes.
Park et al. (2013)
35 more