› 2j6k

X-ray diffraction
2.77Å resolution

N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)

Released:
DOI: 10.2210/pdb2j6k/pdb
PDB entry 2j6k coloured by chain, front view.
PDB entry 2j6k coloured by chain, side view.
PDB entry 2j6k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.
Moncalián G, Cárdenes N, Deribe YL, Spínola-Amilibia M, Dikic I, Bravo J
J Biol Chem 281 38845-53 (2006)
PMID: 17020880

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195277 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD2-associated protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 62 amino acids
Theoretical weight: 7.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5K6 (Residues: 1-62; Coverage: 10%)
Gene name: CD2AP
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: I4
Unit cell:
a: 120.018Å b: 120.018Å c: 153.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.208 0.274
Expression system: Escherichia coli

Quick links

Citations

4 review citations

E3 ubiquitin ligase Cbl-b in innate and adaptive immunity.
Liu et al. (2014)
3 more

1 mention without citation

Structure of the kidney slit diaphragm adapter protein CD2-associated protein as determined with electron microscopy.
Adair et al. (2014)