› 2j8l

Solution NMR

FXI Apple 4 domain loop-out conformation

Released:
DOI: 10.2210/pdb2j8l/pdb
PDB entry 2j8l coloured by chain, ensemble of 14 models, front view.
PDB entry 2j8l coloured by chain, ensemble of 14 models, side view.
PDB entry 2j8l coloured by chain, ensemble of 14 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation.
Samuel D, Cheng H, Riley PW, Canutescu AA, Nagaswami C, Weisel JW, Bu Z, Walsh PN, Roder H
Proc Natl Acad Sci U S A 104 15693-8 (2007)
PMID: 17884987

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137287 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coagulation factor XIa heavy chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 90 amino acids
Theoretical weight: 9.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P03951 (Residues: 290-379; Coverage: 15%)
Gene name: F11
Sequence domains: PAN domain
Structure domains: Hepatocyte Growth Factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: CNS

Quick links

Citations

7 review citations

Structure and function of factor XI.
Emsley et al. (2010)
6 more

1 mention without citation

Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation.
Samuel et al. (2007)