› 2j8p

Solution NMR

NMR structure of C-terminal domain of human CstF-64

Released:
DOI: 10.2210/pdb2j8p/pdb
PDB entry 2j8p coloured by chain, ensemble of 30 models, front view.
PDB entry 2j8p coloured by chain, ensemble of 30 models, side view.
PDB entry 2j8p coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing.
Qu X, Perez-Canadillas JM, Agrawal S, De Baecke J, Cheng H, Varani G, Moore C
J. Biol. Chem. 282 2101-15 (2007)
PMID: 17116658

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152564 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cleavage stimulation factor subunit 2 Chain: A
Molecule details ›
Chain: A
Length: 49 amino acids
Theoretical weight: 5.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P33240 (Residues: 529-577; Coverage: 9%)
Gene name: CSTF2
Sequence domains: Transcription termination and cleavage factor C-terminal
Structure domains: Transcription termination and cleavage factor, C-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Protein factors in pre-mRNA 3'-end processing.
Mandel et al. (2008)
3 more

6 mentions without citation

Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery.
Xiang et al. (2014)
5 more