› 2j9q

X-ray diffraction
2.65Å resolution

A novel conformation for the TPR domain of pex5p

Released:
DOI: 10.2210/pdb2j9q/pdb
PDB entry 2j9q coloured by chain, front view.
PDB entry 2j9q coloured by chain, side view.
PDB entry 2j9q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding.
Stanley WA, Pursiainen NV, Garman EF, Juffer AH, Wilmanns M, Kursula P
BMC Struct Biol 7 24 (2007)
PMID: 17428317

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156217 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisomal targeting signal 1 receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 328 amino acids
Theoretical weight: 36.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P50542 (Residues: 315-639; Coverage: 51%)
Gene names: PEX5, PXR1
Sequence domains: Tetratricopeptide repeat
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

1 bound ligand:
Ligand SR 2 x SR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P212121
Unit cell:
a: 53.67Å b: 91.41Å c: 119.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.241 0.3
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Peroxisome matrix and membrane protein biogenesis.
Ma et al. (2009)
4 more

5 mentions without citation

Development of Novel Anti-Leishmanials: The Case for Structure-Based Approaches.
Soni et al. (2022)
4 more