› 2jak

X-ray diffraction
2.6Å resolution

Human PP2A regulatory subunit B56g

Released:
DOI: 10.2210/pdb2jak/pdb
PDB entry 2jak coloured by chain, front view.
PDB entry 2jak coloured by chain, side view.
PDB entry 2jak coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle.
Magnusdottir A, Stenmark P, Flodin S, Nyman T, Kotenyova T, Gräslund S, Ogg D, Nordlund P
Proteins 74 212-21 (2009)
PMID: 18618707

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171652 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Chain: A
Molecule details ›
Chain: A
Length: 392 amino acids
Theoretical weight: 45.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13362 (Residues: 11-380; Coverage: 71%)
Gene names: KIAA0044, PPP2R5C
Sequence domains: Protein phosphatase 2A regulatory B subunit (B56 family)
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3121
Unit cell:
a: 105.8Å b: 105.8Å c: 82.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.214 0.26
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Functions of B56-containing PP2As in major developmental and cancer signaling pathways.
Yang et al. (2010)
2 more

4 mentions without citation

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization.
Wang et al. (2016)
3 more