2jaw

X-ray diffraction
1.95Å resolution

Crystal structure of D41N variant of human mitochondrial 5'(3')- deoxyribonucleotidase (mdN) in complex with 5-bromovinyldeoxyuridine 5'-monophosphate

Released:

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-192472 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5'(3')-deoxyribonucleotidase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NPB1 (Residues: 32-228; Coverage: 86%)
Gene names: DNT2, NT5M
Sequence domains: 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P43212
Unit cell:
a: 73.604Å b: 73.604Å c: 106.374Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.185 0.216
Expression system: Escherichia coli BL21(DE3)