› 2jeo

X-ray diffraction
2.5Å resolution

Crystal structure of human uridine-cytidine kinase 1

Released:
DOI: 10.2210/pdb2jeo/pdb
PDB entry 2jeo coloured by chain, front view.
PDB entry 2jeo coloured by chain, side view.
PDB entry 2jeo coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kosinska U, Stenmark P, Arrowsmith C, Berglund H, Busam R, Collins R, Edwards A, Ericsson UB, Flodin S, Flores A, Graslund S, Hammarstrom M, Hallberg BM, Holmberg Schiavone L, Hogbom M, Johansson I, Karlberg T, Kotenyova T, Moche M, Nilsson MEP, Nyman T, Ogg D, Persson C, Sagemark J, Sundstrom M, Uppenberg J, Uppsten M, Thorsell AG, van den Berg S, Weigelt J, Welin M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + cytidine = ADP + CMP
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190710 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uridine-cytidine kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 28.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HA47 (Residues: 21-243; Coverage: 81%)
Gene names: UCK1, URK1
Sequence domains: Phosphoribulokinase / Uridine kinase family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P6222
Unit cell:
a: 67.971Å b: 67.971Å c: 236.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.204 0.24
Expression system: Escherichia coli

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