› 2jhh

X-ray diffraction
1.7Å resolution

Structure of globular heads of M-ficolin at acidic pH

Released:
DOI: 10.2210/pdb2jhh/pdb
PDB entry 2jhh coloured by chain, front view.
PDB entry 2jhh coloured by chain, side view.
PDB entry 2jhh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch.
Garlatti V, Martin L, Gout E, Reiser JB, Fujita T, Arlaud GJ, Thielens NM, Gaboriaud C
J Biol Chem 282 35814-20 (2007)
PMID: 17897951

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126363 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ficolin-1 Chains: C, F
Molecule details ›
Chains: C, F
Length: 218 amino acids
Theoretical weight: 24.38 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O00602 (Residues: 109-326; Coverage: 73%)
Gene names: FCN1, FCNM
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P3
Unit cell:
a: 69.4Å b: 69.4Å c: 77.63Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.221 0.219 0.252
Expression system: Trichoplusia ni

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Citations

9 review citations

The role of ficolins in the lectin pathway of innate immunity.
Endo et al. (2011)
8 more