› 2jju

X-ray diffraction
1.19Å resolution

Structure of human signal regulatory protein (sirp) beta

Released:
DOI: 10.2210/pdb2jju/pdb
PDB entry 2jju coloured by chain, front view.
PDB entry 2jju coloured by chain, side view.
PDB entry 2jju coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN
Mol Cell 31 266-77 (2008)
PMID: 18657508

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126193 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Signal-regulatory protein beta-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 14 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: O00241 (Residues: 30-148; Coverage: 32%)
Gene name: SIRPB1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 32.166Å b: 65.172Å c: 58.113Å
α: 90° β: 93.43° γ: 90°
R-values:
R R work R free
0.14 0.139 0.157
Expression system: Cricetulus griseus

Quick links

Citations

37 review citations

The interaction between signal regulatory protein alpha (SIRPĪ±) and CD47: structure, function, and therapeutic target.
Barclay et al. (2014)
36 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)