› 2jjw

X-ray diffraction
1.7Å resolution

Structure of human signal regulatory protein (sirp) gamma

Released:
DOI: 10.2210/pdb2jjw/pdb
PDB entry 2jjw coloured by chain, front view.
PDB entry 2jjw coloured by chain, side view.
PDB entry 2jjw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN
Mol Cell 31 266-77 (2008)
PMID: 18657508

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192815 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Signal-regulatory protein gamma Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.21 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q9P1W8 (Residues: 29-147; Coverage: 33%)
Gene names: SIRPB2, SIRPG
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P6422
Unit cell:
a: 76.39Å b: 76.39Å c: 78.24Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.228 0.267
Expression system: Cricetulus griseus

Quick links

Citations

37 review citations

The interaction between signal regulatory protein alpha (SIRPĪ±) and CD47: structure, function, and therapeutic target.
Barclay et al. (2014)
36 more

1 mention without citation

Crystal structure of signal regulatory protein gamma (SIRPĪ³) in complex with an antibody Fab fragment.
Nettleship et al. (2013)