› 2jng

Solution NMR

Solution structure of the CUL7-CPH domain from Homo Sapiens; Northeast Structural Genomics Consortium target HT1.

Released:
DOI: 10.2210/pdb2jng/pdb
PDB entry 2jng coloured by chain, ensemble of 20 models, front view.
PDB entry 2jng coloured by chain, ensemble of 20 models, side view.
PDB entry 2jng coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.
Kaustov L, Lukin J, Lemak A, Duan S, Ho M, Doherty R, Penn LZ, Arrowsmith CH
J Biol Chem 282 11300-7 (2007)
PMID: 17298945

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172137 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cullin-7 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 12.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14999 (Residues: 360-460; Coverage: 6%)
Gene names: CUL7, KIAA0076
Sequence domains: Mouse development and cellular proliferation protein Cullin-7
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

10 review citations

The cullin protein family.
Sarikas et al. (2011)
9 more

5 mentions without citation

Structure-oriented methods for protein NMR data analysis.
Bermejo et al. (2010)
4 more