› 2jo8

Solution NMR

Solution structure of C-terminal domain of human mammalian sterile 20-like kinase 1 (MST1)

Released:
DOI: 10.2210/pdb2jo8/pdb
PDB entry 2jo8 coloured by chain, ensemble of 20 models, front view.
PDB entry 2jo8 coloured by chain, ensemble of 20 models, side view.
PDB entry 2jo8 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway.
Hwang E, Ryu KS, Pääkkönen K, Güntert P, Cheong HK, Lim DS, Lee JO, Jeon YH, Cheong C
Proc Natl Acad Sci U S A 104 9236-41 (2007)
PMID: 17517604

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171516 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 4 18kDa subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 51 amino acids
Theoretical weight: 6.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q13043 (Residues: 432-480; Coverage: 10%)
Gene names: KRS2, MST1, STK4
Sequence domains: C terminal SARAH domain of Mst1
Structure domains: p53-like tetramerisation domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

30 review citations

The RASSF proteins in cancer; from epigenetic silencing to functional characterization.
Richter et al. (2009)
29 more

9 mentions without citation

Regulation of MST complexes and activity via SARAH domain modifications.
Karchugina et al. (2021)
8 more