› 2jp1

Solution NMR

Solution structure of the alternative conformation of XCL1/Lymphotactin

Released:
DOI: 10.2210/pdb2jp1/pdb
PDB entry 2jp1 coloured by chain, ensemble of 20 models, front view.
PDB entry 2jp1 coloured by chain, ensemble of 20 models, side view.
PDB entry 2jp1 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Interconversion between two unrelated protein folds in the lymphotactin native state.
Tuinstra RL, Peterson FC, Kutlesa S, Elgin ES, Kron MA, Volkman BF
Proc Natl Acad Sci U S A 105 5057-62 (2008)
PMID: 18364395

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155687 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lymphotactin Chains: A, B
Molecule details ›
Chains: A, B
Length: 93 amino acids
Theoretical weight: 10.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P47992 (Residues: 22-114; Coverage: 100%)
Gene names: LTN, SCYC1, XCL1
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: AUTOMATED METHODS WERE USED FOR BACKBONE CHEMICAL SHIFT ASSIGNMENT AND ITERATIVE NOE REFINEMENT. FINAL STRUCTURES WERE OBTAINED BY MOLECULAR DYNAMICS IN EXPLICIT SOLVENT
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Protein dynamism and evolvability.
Tokuriki et al. (2009)
34 more

22 mentions without citation

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function.
Salanga et al. (2011)
21 more