› 2jph

Solution NMR

NMR solution structure of the Rho GTPase binding domain of human plexin-b1

Released:
DOI: 10.2210/pdb2jph/pdb
PDB entry 2jph coloured by chain, ensemble of 20 models, front view.
PDB entry 2jph coloured by chain, ensemble of 20 models, side view.
PDB entry 2jph coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain.
Tong Y, Hota PK, Hamaneh MB, Buck M
Structure 16 246-58 (2008)
PMID: 18275816

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128842 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plexin-B1 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43157 (Residues: 1743-1862; Coverage: 6%)
Gene names: KIAA0407, PLXN5, PLXNB1, SEP
Sequence domains: Plexin cytoplasmic RhoGTPase-binding domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions.
Hota et al. (2012)
7 more

6 mentions without citation

Compensatory and long-range changes in picosecond-nanosecond main-chain dynamics upon complex formation: 15N relaxation analysis of the free and bound states of the ubiquitin-like domain of human plexin-B1 and the small GTPase Rac1.
Bouguet-Bonnet et al. (2008)
5 more