› 2jr7

Solution NMR

Solution structure of human DESR1

Released:
DOI: 10.2210/pdb2jr7/pdb
PDB entry 2jr7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2jr7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2jr7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of human DESR1, a CSL zinc-binding protein.
Wu F, Zhang J, Sun J, Huang H, Ji P, Chu W, Yu M, Yang F, Wu Z, Wu J, Shi Y
Proteins 71 514-8 (2008)
PMID: 18214955

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188505 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Diphthamide biosynthesis protein 3 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 10.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96FX2 (Residues: 1-81; Coverage: 99%)
Gene names: DESR1, DPH3, ZCSL2
Sequence domains: CSL zinc finger
Structure domains: DPH Zinc finger

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Silencing of diphthamide synthesis 3 (Dph3) reduces metastasis of murine melanoma.
Wang et al. (2012)
1 more

3 mentions without citation

Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4.
Thakur et al. (2012)
2 more