› 2jw4

Solution NMR

NMR solution structure of the N-terminal SH3 domain of human Nckalpha

Released:
DOI: 10.2210/pdb2jw4/pdb
PDB entry 2jw4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2jw4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2jw4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Interaction between the N-terminal SH3 domain of Nck-alpha and CD3-epsilon-derived peptides: non-canonical and canonical recognition motifs.
Santiveri CM, Borroto A, Simón L, Rico M, Alarcón B, Jiménez MA
Biochim Biophys Acta 1794 110-7 (2009)
PMID: 18955169

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147690 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH2/SH3 adapter protein NCK1 Chain: A
Molecule details ›
Chain: A
Length: 72 amino acids
Theoretical weight: 8.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16333 (Residues: 1-63; Coverage: 17%)
Gene names: NCK, NCK1
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

2 review citations

SH3 domain ligand binding: What's the consensus and where's the specificity?
Saksela et al. (2012)
1 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)