› 2jxy

Solution NMR

Solution structure of the hemopexin-like domain of MMP12

Released:
DOI: 10.2210/pdb2jxy/pdb
PDB entry 2jxy coloured by chain, ensemble of 20 models, front view.
PDB entry 2jxy coloured by chain, ensemble of 20 models, side view.
PDB entry 2jxy coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12.
Bertini I, Calderone V, Fragai M, Jaiswal R, Luchinat C, Melikian M, Mylonas E, Svergun DI
J Am Chem Soc 130 7011-21 (2008)
PMID: 18465858

Function and Biology Details

Reaction catalysed: 
Hydrolysis of soluble and insoluble elastin (1). Specific cleavages are also produced at -Ala(14)-|-Leu- and -Tyr(16)-|-Leu- in the B chain of insulin (2).
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage metalloelastase Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 23.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P39900 (Residues: 278-470; Coverage: 43%)
Gene names: HME, MMP12
Sequence domains: Hemopexin
Structure domains: Hemopexin-like domain

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering.
Bernadó et al. (2012)
10 more

2 mentions without citation

Silencing motifs in the Clr2 protein from fission yeast, Schizosaccharomyces pombe.
Steinhauf et al. (2014)
1 more