› 2jy8

Solution NMR

NMR structure of the ubiquitin associated (UBA) domain of p62 (SQSTM1) in complex with ubiquitin. RDC refined

Released:
DOI: 10.2210/pdb2jy8/pdb
PDB entry 2jy8 coloured by chain, ensemble of 21 models, front view.
PDB entry 2jy8 coloured by chain, ensemble of 21 models, side view.
PDB entry 2jy8 coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch.
Long J, Gallagher TR, Cavey JR, Sheppard PW, Ralston SH, Layfield R, Searle MS
J Biol Chem 283 5427-40 (2008)
PMID: 18083707

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171721 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sequestosome-1 Chain: A
Molecule details ›
Chain: A
Length: 52 amino acids
Theoretical weight: 5.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13501 (Residues: 387-436; Coverage: 11%)
Gene names: ORCA, OSIL, SQSTM1
Sequence domains: UBA domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

32 review citations

Selective autophagy mediated by autophagic adapter proteins.
Johansen et al. (2011)
31 more