› 2jyi

Solution NMR

Solution structure of MLL CXXC domain

Released:
DOI: 10.2210/pdb2jyi/pdb
PDB entry 2jyi coloured by chain, ensemble of 14 models, front view.
PDB entry 2jyi coloured by chain, ensemble of 14 models, side view.
PDB entry 2jyi coloured by chain, ensemble of 14 models, top view.
Source organism: Homo sapiens
Entry authors: Cierpicki T, Bushweller JH

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169856 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MLL cleavage product N320 Chain: A
Molecule details ›
Chain: A
Length: 57 amino acids
Theoretical weight: 6.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03164 (Residues: 1147-1203; Coverage: 1%)
Gene names: ALL1, CXXC7, HRX, HTRX, KMT2A, MLL, MLL1, TRX1
Sequence domains: CXXC zinc finger domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, distance geometry
Expression system: Escherichia coli

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