› 2k1d

Solution NMR

NMR Studies of a Pathogenic Mutant (D178N) of the Human Prion Protein

Released:
DOI: 10.2210/pdb2k1d/pdb
PDB entry 2k1d coloured by chain, ensemble of 20 models, front view.
PDB entry 2k1d coloured by chain, ensemble of 20 models, side view.
PDB entry 2k1d coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Mills JL, Surewicz K, Surewicz WK, Sonnichsen FD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137455 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04156 (Residues: 90-231; Coverage: 62%)
Gene names: ALTPRP, PRIP, PRNP, PRP
Sequence domains: Prion/Doppel alpha-helical domain
Structure domains: Prion/Doppel protein, beta-ribbon domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: simulated annealing, TORSION ANGLE DYNAMICS
Expression system: Escherichia coli

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