› 2k1r

Solution NMR

The solution NMR structure of the complex between MNK1 and HAH1 mediated by Cu(I)

Released:
DOI: 10.2210/pdb2k1r/pdb
PDB entry 2k1r coloured by chain, ensemble of 20 models, front view.
PDB entry 2k1r coloured by chain, ensemble of 20 models, side view.
PDB entry 2k1r coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Bertini I, Banci LC, Felli IC, Pavelkova A, Rosato A, Structural Proteomics in Europe (SPINE)

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126195 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Copper-transporting ATPase 1 Chain: A
Molecule details ›
Chain: A
Length: 73 amino acids
Theoretical weight: 8.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04656 (Residues: 5-77; Coverage: 5%)
Gene names: ATP7A, MC1, MNK
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits
Copper transport protein ATOX1 Chain: B
Molecule details ›
Chain: B
Length: 68 amino acids
Theoretical weight: 7.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00244 (Residues: 1-68; Coverage: 100%)
Gene names: ATOX1, HAH1
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

1 bound ligand:
Ligand CU 1 x CU
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli

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