› 2k4a

Solution NMR

FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway

Released:
DOI: 10.2210/pdb2k4a/pdb
PDB entry 2k4a coloured by chain, ensemble of 20 models, front view.
PDB entry 2k4a coloured by chain, ensemble of 20 models, side view.
PDB entry 2k4a coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Yu C, Mohan SK

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138605 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Synaptotagmin-1 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21579 (Residues: 141-268; Coverage: 30%)
Gene names: SVP65, SYT, SYT1
Sequence domains: C2 domain
Structure domains: C2 domain
Fibroblast growth factor 1 Chain: B
Molecule details ›
Chain: B
Length: 133 amino acids
Theoretical weight: 15.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05230 (Residues: 23-155; Coverage: 86%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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