› 2k4p

Solution NMR

Solution Structure of Ship2-Sam

Released:
DOI: 10.2210/pdb2k4p/pdb
PDB entry 2k4p coloured by chain, ensemble of 20 models, front view.
PDB entry 2k4p coloured by chain, ensemble of 20 models, side view.
PDB entry 2k4p coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR studies of a heterotypic Sam-Sam domain association: the interaction between the lipid phosphatase Ship2 and the EphA2 receptor.
Leone M, Cellitti J, Pellecchia M
Biochemistry 47 12721-8 (2008)
PMID: 18991394

Function and Biology Details

Reaction catalysed: 
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127447 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15357 (Residues: 1194-1258; Coverage: 5%)
Gene names: INPPL1, SHIP2
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Eph-dependent cell-cell adhesion and segregation in development and cancer.
Nievergall et al. (2012)
7 more

9 mentions without citation

Hunting for Novel Routes in Anticancer Drug Discovery: Peptides against Sam-Sam Interactions.
Mercurio et al. (2022)
8 more