› 2k6o

Solution NMR

Human LL-37 Structure

Released:
DOI: 10.2210/pdb2k6o/pdb
PDB entry 2k6o coloured by chain, ensemble of 4 models, front view.
PDB entry 2k6o coloured by chain, ensemble of 4 models, side view.
PDB entry 2k6o coloured by chain, ensemble of 4 models, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles.
Wang G
J Biol Chem 283 32637-43 (2008)
PMID: 18818205

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156078 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antibacterial peptide LL-37 Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 4.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49913 (Residues: 134-170; Coverage: 26%)
Gene names: CAMP, CAP18, FALL39, HSD26
Sequence domains: LPS binding domain of CAP18 (C terminal)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

42 review citations

A comprehensive summary of LL-37, the factotum human cathelicidin peptide.
Vandamme et al. (2012)
41 more

72 mentions without citation

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents.
Mahlapuu et al. (2016)
71 more