› 2kaw

Solution NMR

NMR structure of the mDvl1 PDZ domain in complex with its inhibitor

Released:
DOI: 10.2210/pdb2kaw/pdb
PDB entry 2kaw coloured by chain, ensemble of 20 models, front view.
PDB entry 2kaw coloured by chain, ensemble of 20 models, side view.
PDB entry 2kaw coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.
Lee HJ, Wang NX, Shi DL, Zheng JJ
Angew Chem Int Ed Engl 48 6448-52 (2009)
PMID: 19637179

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156295 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Segment polarity protein dishevelled homolog DVL-1 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 9.63 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P51141 (Residues: 248-337; Coverage: 13%)
Gene names: Dvl, Dvl1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand SUZ 1 x SUZ
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, HADDOCK
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update.
Takebe et al. (2015)
20 more

6 mentions without citation

Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition.
Liu et al. (2019)
5 more