› 2kb8

Solution NMR

The dynamic alpha-helix structure of micelle-bound human amylin.

Released:
DOI: 10.2210/pdb2kb8/pdb
PDB entry 2kb8 coloured by chain, ensemble of 30 models, front view.
PDB entry 2kb8 coloured by chain, ensemble of 30 models, side view.
PDB entry 2kb8 coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Dynamic alpha-helix structure of micelle-bound human amylin.
Patil SM, Xu S, Sheftic SR, Alexandrescu AT
J Biol Chem 284 11982-91 (2009)
PMID: 19244249

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145613 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Islet amyloid polypeptide Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 3.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10997 (Residues: 34-70; Coverage: 55%)
Gene name: IAPP
Sequence domains: Calcitonin / CGRP / IAPP family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.
Westermark et al. (2011)
8 more

28 mentions without citation

Implications of peptide assemblies in amyloid diseases.
Ke et al. (2017)
27 more